ICSI Treatment in Indore for Male-Factor Infertility
ICSI injects one sperm into each egg to help when sperm count or movement is low, or fertilisation failed before. Learn the process, risks and who needs it.
Intracytoplasmic sperm injection (ICSI) is an advanced IVF laboratory technique in which an embryologist injects a single selected sperm directly into each mature egg. It has transformed the outlook for couples facing male-factor infertility. At Asian Navkar Hospital, Indore, ICSI is performed by experienced clinical embryologists, and it is advised only when it genuinely adds benefit over conventional IVF.
When Is ICSI Recommended?
- Low sperm count (oligozoospermia), poor movement (asthenozoospermia) or abnormal shape (teratozoospermia)
- No sperm in the semen (azoospermia), using sperm retrieved by TESA or micro-TESE
- Very few frozen sperm, including single sperm vitrification samples
- Failed or very low fertilisation in a previous IVF cycle
- Use of previously frozen eggs
- Cycles where PGT is planned, to avoid contamination from extra sperm
For couples with normal semen and no previous fertilisation problem, international guidance (including ESHRE) notes that ICSI does not improve live birth rates over conventional IVF, so we do not use it routinely without a reason.
How ICSI Is Performed
ICSI follows the same steps as IVF for the woman: ovarian stimulation, monitoring and egg collection. The difference is in the laboratory:
- Eggs are cleaned of surrounding cells and checked for maturity.
- A semen sample is prepared, or sperm is retrieved surgically.
- Under a high-powered microscope, the embryologist immobilises a single healthy-looking sperm and injects it into the centre of each mature egg using a fine glass needle.
- Fertilisation is checked the next day, and embryos are cultured for 3–5 days.
- The best embryo is transferred, and suitable extra embryos can be frozen.
Male Infertility Evaluation Before ICSI
Before choosing ICSI, the male partner is evaluated properly. This may include repeat semen analysis, hormone tests (FSH, LH, testosterone, prolactin), scrotal ultrasound and, when counts are very low or absent, genetic tests such as karyotype and Y-chromosome microdeletion. Treatable causes such as varicocele, infection, hormonal problems or lifestyle factors are addressed where possible. Dr. Dinesh Jain, Chief Clinical Embryologist at Asian Navkar Hospital, has a special interest in severe male infertility.
Is ICSI Safe?
ICSI has been used worldwide for over three decades and most children born after ICSI are healthy. Some studies show a small increase in certain birth defects and genetic conditions compared with natural conception, partly linked to the underlying sperm problem rather than the technique itself. Where the male partner has a genetic cause for infertility, genetic counselling is offered before treatment. Rarely, an egg may be damaged during injection.
ICSI Success Factors
Most mature eggs that are injected fertilise, but not every fertilised egg becomes a good-quality embryo. Pregnancy chances after ICSI depend mainly on the woman's age and egg quality, as with IVF, along with the source and quality of sperm and the health of the uterus. Your doctor will give you a realistic estimate after reviewing reports from both partners.
Why Families Choose Asian Navkar Hospital, Indore
- Fertility, embryology, high-risk obstetrics and a Level 3 NICU in one hospital, so care continues after a positive pregnancy test.
- Senior IVF team with 30+ years of clinical experience, including clinical embryologists.
- Counselling for both partners, transparent written estimates and cashless TPA/insurance desk support where policies allow.
Related Services
- IVF Clinic in Indore
- TESA Procedure in Indore
- Micro TESE in Indore
- Sperm Freezing in Indore, Including Single Sperm Vitrification
- Fertility Test in Indore
Medical References
- HFEA - Fertility treatments explained
- ESHRE guidelines
- NHS - Infertility treatment
- WHO - Infertility fact sheet
This page is for general information and does not replace a consultation. Treatment decisions are made only after an in-person evaluation by a qualified doctor at Asian Navkar Hospital, Indore.
Is this for you?
How We Treat Intracytoplasmic Sperm Injection (ICSI)
Frequently Asked Questions
In conventional IVF, sperm and eggs are placed together and fertilisation happens on its own. In ICSI, the embryologist injects one sperm directly into each egg. ICSI is part of an IVF cycle, used mainly for male-factor problems.
Often yes. If sperm is being produced in the testes, it can be retrieved by TESA or micro-TESE and used for ICSI. A specialist will assess this with hormone and genetic tests.
No treatment can guarantee pregnancy. ICSI helps achieve fertilisation, but pregnancy depends on embryo quality, the woman's age and the uterus.
ICSI adds laboratory time and skill, so it usually costs more than conventional IVF. We include it in your written estimate only if it is medically indicated.
The woman's experience is the same as IVF. Egg collection is done under short anaesthesia, and the ICSI step itself happens in the laboratory.
Most are. There is a small increased risk of some conditions, often related to the father's sperm problem. Genetic counselling is offered when needed.
Dr. Vedant Jain is an IVF Consultant, Gynecologist, and Certified Embryologist at Asian Navkar Hospital, Indore. Holding post-graduate degrees including an MS and DNB in Obstetrics and Gynecology, he practises reproductive medicine at Asian Navkar Hospital. Dr. Jain specializes in advanced Assisted Reproductive Technologies (ART), complex infertility assessments, low AMH (ovarian reserve) optimization, and fertility preservation. By combining clinical gynecology with laboratory embryology, he works with couples who have had unsuccessful IVF cycles to plan further evaluation and treatment.
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