PGT-M in Indore: Testing Embryos for Inherited Single-Gene Disorders
PGT-M tests IVF embryos for a known family genetic disease such as thalassaemia, so an unaffected embryo can be transferred. Learn the steps and accuracy.
PGT-M (preimplantation genetic testing for monogenic disorders) helps couples who know they carry a serious inherited condition, such as beta-thalassaemia, sickle cell disease or spinal muscular atrophy, to have a baby who is not affected by that condition. At Asian Navkar Hospital, Indore, PGT-M is planned together with genetic counsellors and specialised genetic laboratories.
Who Is PGT-M For?
- Couples where both partners are carriers of the same recessive disorder (for example, both thalassaemia carriers)
- A partner with a dominant genetic condition
- Families with an X-linked disorder
- Couples who already have an affected child
A confirmed genetic diagnosis (the exact mutation) in the family is needed before testing can be designed.
Steps in PGT-M
- Genetic counselling and confirmation of the family mutation
- Creation of a test specific to your family (this can take several weeks)
- IVF with ICSI, embryo biopsy and freezing
- Transfer of an embryo reported as unaffected
- Confirmation by prenatal testing during pregnancy is recommended
Accuracy and Limits
PGT-M is highly accurate for the condition tested but is not perfect, and it does not test for other conditions. The number of unaffected embryos depends on the inheritance pattern and how many embryos are available.
Why Families Choose Asian Navkar Hospital, Indore
- Fertility, embryology, high-risk obstetrics and a Level 3 NICU in one hospital, so care continues after a positive pregnancy test.
- Senior IVF team with 30+ years of clinical experience, including clinical embryologists.
- Counselling for both partners, transparent written estimates and cashless TPA/insurance desk support where policies allow.
Related Services
- Genetic Counselling in Indore for Couples and Families
- PGT Testing in Indore
- IVF Clinic in Indore
- Fertility Centre in Indore
Medical References
This page is for general information and does not replace a consultation. Treatment decisions are made only after an in-person evaluation by a qualified doctor at Asian Navkar Hospital, Indore.
Is this for you?
How We Treat PGT-M (Monogenic Disorder Testing)
Frequently Asked Questions
If both parents are carriers, PGT-M can identify embryos not affected by thalassaemia major for transfer.
Yes. The exact mutations in the family must be known to design the test.
Test design can take several weeks; IVF and testing then follow. Your team will share a timeline.
Confirmation by CVS or amniocentesis is generally recommended.
No. Sex selection is illegal in India under the PC-PNDT Act.
Dr. Vedant Jain is an IVF Consultant, Gynecologist, and Certified Embryologist at Asian Navkar Hospital, Indore. Holding post-graduate degrees including an MS and DNB in Obstetrics and Gynecology, he practises reproductive medicine at Asian Navkar Hospital. Dr. Jain specializes in advanced Assisted Reproductive Technologies (ART), complex infertility assessments, low AMH (ovarian reserve) optimization, and fertility preservation. By combining clinical gynecology with laboratory embryology, he works with couples who have had unsuccessful IVF cycles to plan further evaluation and treatment.
Ready for a PGT-M (Monogenic Disorder Testing) consultation?
Share details, our team will call for a private, no-pressure consultation.